Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. - Wikidata - awgldk - TriplyDB

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.

http://www.wikidata.org/entity/Q40335692

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Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity Metabolic methanol: molecular pathways and physiological roles Altered retinoic acid metabolism in diabetic mouse kidney identified by O isotopic labeling and 2D mass spectrometry.Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells Tetracarpidium conophorum ameliorates oxidative reproductive toxicity induced by ethanol in male rats.Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.CYP2E1 and oxidative liver injury by alcohol.Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.Mechanism of alcohol-induced oxidative stress and neuronal injury.Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa.Anionic phospholipid-induced regulation of reactive oxygen species production by human cytochrome P450 2E1.1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.Toxicological Implications of Mitochondrial Localization of CYP2E1.L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury.Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.

P2860

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P2860

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.

http://www.wikidata.org/entity/Q40335692

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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name

Overexpression of CYP2E1 in mi ...... d by depletion of glutathione.

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Overexpression of CYP2E1 in mi ...... d by depletion of glutathione.

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Overexpression of CYP2E1 in mi ...... d by depletion of glutathione.

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Journal of Biological Chemistry

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Overexpression of CYP2E1 in mi ...... d by depletion of glutathione.

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Arthur I Cederbaum

http://www.w3.org/2001/XMLSchema#string

Jingxiang Bai

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P2860

Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity

Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus

Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy.

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats.

Oxidative damage during aging targets mitochondrial aconitase

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.

The mitochondrial permeability transition.

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane.

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5128-5136

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scholarly article

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10.1074/JBC.M510484200

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8

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281

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2005-12-27T00:00:00Z

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16380384

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