Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.
about
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP114-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerDNA damage control: regulation and functions of checkpoint kinase 1Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designRoles of Chk1 in cell biology and cancer therapyDNA damage response genes and the development of cancer metastasisPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointToxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpointVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signalingLoss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging AgentsHeterogeneous nuclear ribonucleoprotein A2/B1 is a tissue-specific aldosterone target gene with prominent induction in the rat distal colonUSP37 deubiquitinates Cdt1 and contributes to regulate DNA replicationATR: an essential regulator of genome integrityCdk2 is required for p53-independent G2/M checkpoint control.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Chromatin at the intersection of viral infection and DNA damageThe anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sitesATR autophosphorylation as a molecular switch for checkpoint activation.Regulation of HuR by DNA Damage Response Kinases.The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoProtein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.Replication licensing and the DNA damage checkpoint.AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts.Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Epigenetic mechanisms and genome stability.BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survivalCheckpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy responseKey mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes.
P2860
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P2860
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Rapid PIKK-dependent release o ...... NA-damage checkpoint response.
@en
type
label
Rapid PIKK-dependent release o ...... NA-damage checkpoint response.
@en
prefLabel
Rapid PIKK-dependent release o ...... NA-damage checkpoint response.
@en
P1433
P1476
Rapid PIKK-dependent release o ...... DNA-damage checkpoint response
@en
P2093
Philip M Reaper
P304
P356
10.1016/J.CUB.2005.11.066
P407
P577
2005-12-15T00:00:00Z