Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo - Wikidata - awgldk - TriplyDB

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

http://www.wikidata.org/entity/Q34241074

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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy Ataxia-telangiectasia: future prospects TSPYL2 is important for G1 checkpoint maintenance upon DNA damage.Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme.CHK2 kinase in the DNA damage response and beyond Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1 Modelling the onset of senescence at the G1/S cell cycle checkpoint.Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.Characterization of the role of Fhit in suppression of DNA damage.CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.The ATM signaling network in development and disease.Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro The MRE11 complex: starting from the ends.Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.Cell cycle proteins as promising targets in cancer therapy Caspases and cancer.Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review.Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation.Anticarcinogenic effects of the ethanolic extract of Salix aegyptiaca in colon cancer cells: involvement of Akt/PKB and MAPK pathways.CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.Checkpoint kinase 2 is required for efficient immunoglobulin diversification.Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5'-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells.Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database.Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

http://www.wikidata.org/entity/Q34241074

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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type

label

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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prefLabel

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

@ast

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

@en

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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The EMBO Journal

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

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Aik Kia Khaw

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Birendranath Banerjee

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Ettore Appella

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Hidetsugu Fujigaki

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Hiroyuki Niida

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Ichiro Miyoshi

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Kazuhiro Murata

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Kumiko Ogawa

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Kumiko Ohta

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Kyoko Suzuki

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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3558-3570

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scholarly article

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10.1038/EMBOJ.2010.218

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20

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29

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M Prakash Hande

Mireille Delhase

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2010-09-10T00:00:00Z

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46220726

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20834228

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2964167

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