Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans.

Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans.

Item
http://www.wikidata.org/entity/Q40343599
Biopharmaceutical characterization of decursin and their derivatives for drug discoveryEvaluation of various static and dynamic modeling methods to predict clinical CYP3A induction using in vitro CYP3A4 mRNA induction data.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs.Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Evaluation of models for predicting drug-drug interactions due to induction.Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices.Advances in predicting CYP-mediated drug interactions in the drug discovery setting.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates.
P2860

Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans.

Item
http://www.wikidata.org/entity/Q40343599
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Evaluation of human liver slic ...... al of drugs in vivo in humans.
@en
type
label
Evaluation of human liver slic ...... al of drugs in vivo in humans.
@en
prefLabel
Evaluation of human liver slic ...... al of drugs in vivo in humans.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Evaluation of human liver slic ...... al of drugs in vivo in humans.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698