Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism
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Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factorsRegulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 proteinThe hsp90 chaperone complex regulates intracellular localization of the dioxin receptorProtein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complexLigand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptorEvidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptorDefining the role for XAP2 in stabilization of the dioxin receptorActivation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factorDefinition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificityPAS domains: internal sensors of oxygen, redox potential, and lightSOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responsesA dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins.Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator.Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factorDown-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor.Phosphorylation of xenobiotic-metabolizing cytochromes P450.Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element.Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt.The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation.Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism.Identification of a novel domain in the aryl hydrocarbon receptor required for DNA binding.Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer.Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds.Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt.The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains.Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl)benzothiazole in breast cancer cell lines.Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans.Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.Differential usage of nuclear export sequences regulates intracellular localization of the dioxin (aryl hydrocarbon) receptor.Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.A mutation in the aryl hydrocarbon receptor (AHR) in a cultured mammalian cell line identifies a novel region of AHR that affects DNA binding.Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of Ha-ras oncogenes.Regulation of dioxin receptor function by omeprazole.Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene.
P2860
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P2860
Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@ast
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@en
type
label
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@ast
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@en
prefLabel
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@ast
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@en
P2093
P2860
P356
P1476
Cross-coupling of signal trans ...... n kinase C-dependent mechanism
@en
P2093
A Berghard
I Pongratz
L Poellinger
M Whitelaw
P2860
P304
P356
10.1128/MCB.13.1.677
P407
P577
1993-01-01T00:00:00Z