TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
about
Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS PhenotypeTRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune CellsModulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.Transient receptor potential channels and regulation of lung endothelial permeability.Cellular functions of transient receptor potential channels.Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells.Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels.Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell deathTipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channelsInhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cellsGenome-wide Association Study on Platinum-induced Hepatotoxicity in Non-Small Cell Lung Cancer Patients.Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent MannerEnhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel.Role of TRPM2 in cell proliferation and susceptibility to oxidative stressIntracellular calcium activates TRPM2 and its alternative spliced isoforms.Identification and functional characterization of ion channels in CD34(+) hematopoietic stem cells from human peripheral blood.Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosisPharmacology of transient receptor potential melastatin channels in the vasculatureReview: NAD +: a modulator of immune functions.TRPM2 channel properties, functions and therapeutic potentials.The role of transient receptor potential cation channels in Ca2+ signalingProperties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.TRPM channels: same ballpark, different players, and different rules in immunogenetics.The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation.Role of TRP ion channels in cancer and tumorigenesis.ROS-activated calcium signaling mechanisms regulating endothelial barrier function.Crosstalk between calcium and reactive oxygen species signaling in cancer.Effect of ionic stress on apoptosis and the expression of TRPM2 in human olfactory neuroepithelial-derived progenitors.Requirement for the N-terminal coiled-coil domain for expression and function, but not subunit interaction of, the ADPR-activated TRPM2 channelThe Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.Oxidation induces ClC-3-dependent anion channels in human leukaemia cells.Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferationTransient Receptor Potential-Melastatin Channel Family Member 2: Friend or FoePlacing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.TRPM2 Ca2+ channel regulates energy balance and glucose metabolism.Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore.Role of TRPM2 cation channels in dorsal root ganglion of rats after experimental spinal cord injury.
P2860
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P2860
TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
TRPM2 is an ion channel that m ...... of caspases and PARP cleavage.
@en
type
label
TRPM2 is an ion channel that m ...... of caspases and PARP cleavage.
@en
prefLabel
TRPM2 is an ion channel that m ...... of caspases and PARP cleavage.
@en
P2093
P2860
P1476
TRPM2 is an ion channel that m ...... of caspases and PARP cleavage
@en
P2093
Barbara A Miller
David J Carey
Dwayne L Barber
Iwona Hirschler-Laszkiewicz
Joseph Y Cheung
Kathleen Conrad
Richard Stahl
Shao-Cong Sun
Wenyi Zhang
P2860
P304
P356
10.1152/AJPCELL.00205.2005
P50
P577
2005-11-23T00:00:00Z