Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.
about
Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.Designer small molecules to target calcium signalling.Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2.2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues.TRPM2: a candidate therapeutic target for treating neurological diseases.Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity.
P2860
Q30402082-78E5A377-424F-4D7B-87C0-209D4E7E004BQ35640902-B63BA91D-9557-4B97-98DA-F42769DA7EB3Q39990488-C0D205FF-63C0-477E-AEC7-2919BE784CD5Q42216129-9D0D36EA-BD60-4C8C-AC6E-A18CB9509D63Q46341461-BD7CF2C6-7A11-471D-8A18-E41303BCB465Q48184032-ED8A5AEA-4CCA-463A-8DEA-2F8A3F842036Q52578572-06A8E090-47BE-4122-9689-EDBABB41E001Q55063295-068029DB-CE25-499E-9CD0-073163436362Q55245338-1E17569D-836B-4EE1-9D71-3F49F8A032D0
P2860
Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Structure-activity relationshi ...... ational design of antagonists.
@en
Structure-activity relationshi ...... eceptor potential melastatin 2
@nl
type
label
Structure-activity relationshi ...... ational design of antagonists.
@en
Structure-activity relationshi ...... eceptor potential melastatin 2
@nl
prefLabel
Structure-activity relationshi ...... ational design of antagonists.
@en
Structure-activity relationshi ...... eceptor potential melastatin 2
@nl
P2093
P2860
P356
P1476
Structure-activity relationshi ...... ational design of antagonists.
@en
P2093
Andreas Bauche
Andreas H Guse
Angelika Harneit
Barry V L Potter
Christelle Moreau
Ralf Fliegert
Stephen J Bartlett
Tanja Kirchberger
Timur Yorgan
P2860
P304
10079-10102
P356
10.1021/JM401497A
P407
P577
2013-12-13T00:00:00Z