Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.
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Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinPresence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsSerine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorHuman mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chainsPulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast.Small molecule inhibitors of mesotrypsin from a structure-based docking screen.Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancerProteinases and signalling: pathophysiological and therapeutic implications via PARs and more.Biochemical and structural insights into mesotrypsin: an unusual human trypsin.Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2.PAR-2 activation and LPS synergistically enhance inflammatory signaling in airway epithelial cells by raising PAR expression level and interleukin-8 release.Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine. A possible means to regulate gene expression.Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.
P2860
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P2860
Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Activity of recombinant trypsi ...... weakly activates brain PAR-1.
@en
type
label
Activity of recombinant trypsi ...... weakly activates brain PAR-1.
@en
prefLabel
Activity of recombinant trypsi ...... weakly activates brain PAR-1.
@en
P2093
P2860
P356
P1476
Activity of recombinant trypsi ...... t weakly activates brain PAR-1
@en
P2093
Ewa Ostrowska
Georg Reiser
Walter Halangk
Zoryana Grishina
P2860
P304
P356
10.1038/SJ.BJP.0706410
P407
P577
2005-12-01T00:00:00Z