Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes.
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Role of pregnane X receptor in chemotherapeutic treatmentPrimary hepatocytes and their cultures in liver apoptosis researchActivation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cellsThe protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptorA functional polymorphism in the 3'-UTR of PXR interacts with smoking to increase lung cancer risk in southern and eastern Chinese smokerPregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Neurosteroids reduce inflammation after TBI through CD55 induction.Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer.Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.The antiapoptotic role of pregnane X receptor in human colon cancer cells.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Expression of the PXR gene in various types of cancer and drug resistanceA concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet.Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms.Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.Pregnane X Receptor and Cancer: Context-Specificity is Key.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.PXR cross-talks with internal and external signals in physiological and pathophysiological responses.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells.Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma.Effect of clotrimazole on cytosolic Ca(2+) rise and viability in HA59T human hepatoma cells.Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells.Yeast caspase-dependent apoptosis in Saccharomyces cerevisiae BY4742 induced by antifungal and potential antitumor agent clotrimazole.Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response.Progesterone treatment shows greater protection in brain vs. retina in a rat model of middle cerebral artery occlusion: Progesterone receptor levels may play an important role.PXR: More Than Just a Master Xenobiotic Receptor.The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma.
P2860
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P2860
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Regulation of Bcl-2 and Bcl-xL ...... of human and rat hepatocytes.
@en
type
label
Regulation of Bcl-2 and Bcl-xL ...... of human and rat hepatocytes.
@en
prefLabel
Regulation of Bcl-2 and Bcl-xL ...... of human and rat hepatocytes.
@en
P2093
P1476
Regulation of Bcl-2 and Bcl-xL ...... of human and rat hepatocytes.
@en
P2093
Georges de Sousa
Géraldine Lemaire
Jean Gugenheim
Nathalie Zucchini
Roger Rahmani
P356
10.1016/J.BBAMCR.2005.02.005
P577
2005-03-18T00:00:00Z