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Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerizationEffect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications.High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.Recruitment of governing elements for electron transfer in the nitric oxide synthase familySuperoxide generation by endothelial nitric oxide synthase: the influence of cofactors.Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase.Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide.Kinetics of NO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry.Autoinhibition of endothelial nitric-oxide synthase. Identification of an electron transfer control element.Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.Relative importance of nitric oxide and carbon monoxide in regulating the ACTH response to immune and non-immune signals.A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.Kinetics of CO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry.The function of the small insertion in the hinge subdomain in the control of constitutive mammalian nitric-oxide synthases.Neuronal nitric oxide synthase. Expression in Escherichia coli, irreversible inhibition by phenyldiazene, and active site topology.Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.Active site topologies and cofactor-mediated conformational changes of nitric-oxide synthases.Chimeric enzymes of cytochrome P450 oxidoreductase and neuronal nitric-oxide synthase reductase domain reveal structural and functional differences.Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes.Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase.The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase. A site-directed mutagenesis study.Modulation of the remote heme site geometry of recombinant mouse neuronal nitric-oxide synthase by the N-terminal hook region.Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.Oxygen metabolism by endothelial nitric-oxide synthaseElectron transfer by neuronal nitric-oxide synthase is regulated by concerted interaction of calmodulin and two intrinsic regulatory elementsThe C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain
P2860
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P2860
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Nitric oxide synthases: why so complex?
@en
type
label
Nitric oxide synthases: why so complex?
@en
prefLabel
Nitric oxide synthases: why so complex?
@en
P1476
Nitric oxide synthases: why so complex?
@en
P2093
Masters BS
P304
P356
10.1146/ANNUREV.NU.14.070194.001023
P407
P577
1994-01-01T00:00:00Z