Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.
about
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma.Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanomaTargeting mutant BRAF in melanoma: current status and future development of combination therapy strategiesThe current state of targeted therapy in melanoma: this time it's personalBRAF(E600) in benign and malignant human tumours.Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival.Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene.Melanoma biology and the promise of zebrafish.Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site.Melanocytes in development and cancer.Developmental pathways activated in melanocytes and melanoma.The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo.Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.
P2860
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P2860
Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Growth factors rescue cutaneou ...... wn of mutated (V 600 E) B-RAF.
@en
type
label
Growth factors rescue cutaneou ...... wn of mutated (V 600 E) B-RAF.
@en
prefLabel
Growth factors rescue cutaneou ...... wn of mutated (V 600 E) B-RAF.
@en
P2860
P356
P1433
P1476
Growth factors rescue cutaneou ...... wn of mutated (V 600 E) B-RAF.
@en
P2093
Claus Christensen
Per Guldberg
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208758
P407
P577
2005-09-01T00:00:00Z
P5875
P6179
1050930151