Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.

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Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.

P2860

Q34399659-FB3B578E-30F9-4F57-BD9F-2D1F53D02E25

P2860

Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.

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http://www.wikidata.org/entity/Q40402188

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2005 nî lūn-bûn

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2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

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2005年论文

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name

Silencing of the mutant SCAP a ...... selected for NPC1 expression.

@en

type

Item

label

Silencing of the mutant SCAP a ...... selected for NPC1 expression.

@en

prefLabel

Silencing of the mutant SCAP a ...... selected for NPC1 expression.

@en

P1476

Silencing of the mutant SCAP a ...... selected for NPC1 expression.

@en

P2093

Jean Ann Maguire

http://www.w3.org/2001/XMLSchema#string

Jerry W Reagan

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P2860

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

P304

1840-1848

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P31

scholarly article

P356

10.1194/JLR.M500198-JLR200

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2005-07-01T00:00:00Z

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P698

15995170

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Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.

about

P2860

P2860

Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698