The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
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The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complexUnexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteinsBEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesismiR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β.A requirement for Lim domain binding protein 1 in erythropoiesis.Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.LMO2 induces T-cell leukemia with epigenetic deregulation of CD4PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGALPromiscuous partnerships in Ewing's sarcoma.Leukaemia -- a developmental perspective.Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.Vascular-targeted cancer gene therapy.Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy.Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus.Cutting edge: Natural helper cells derive from lymphoid progenitors.Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy.Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.Asynchronous RAG-1 expression during B lymphopoiesis.LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitorsLMO2 at 25 years: a paradigm of chromosomal translocation proteins.Efficient production of T cells from mouse pluripotent stem cells by controlled expression of Lhx2.BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody.Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter.alpha-L-iduronidase therapy for mucopolysaccharidosis type I.NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection.lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.Tissue- and tumor-specific targeting of murine leukemia virus-based replication-competent retroviral vectors.DNA methylation dynamics during in vivo differentiation of blood and skin stem cells.Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma.Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
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P2860
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en-gb
type
label
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en-gb
prefLabel
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en-gb
P2093
P2860
P1476
The LMO2 T-cell oncogene is ac ...... in normal T-cell development.
@en
P2093
Alan Forster
Lesley Drynan
Richard Pannell
P2860
P304
P356
10.1128/MCB.23.24.9003-9013.2003
P407
P577
2003-12-01T00:00:00Z