Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. - Wikidata - awgldk - TriplyDB

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.

http://www.wikidata.org/entity/Q40415765

about

Fingolimod for the treatment of neurological diseases-state of play and future perspectives Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion Golgi protein FAPP2 tubulates membranes Cross-talk of membrane lipids and Alzheimer-related proteins.Deregulation of sphingolipid metabolism in Alzheimer's disease.Viable mouse gene ablations that robustly alter brain Aβ levels are rare.Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice Multiple roles for sphingolipids in steroid hormone biosynthesis Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APP and APP/PS1 Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous system Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation.Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Cigarette Smoke-Induced Alterations in Frontal White Matter Lipid Profiles Demonstrated by MALDI-Imaging Mass Spectrometry: Relevance to Alzheimer's Disease The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden.LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review Alzheimer's disease: the lipid connection.Evidence for disruption of sphingolipid metabolism in schizophrenia.Substrate specificity of gamma-secretase and other intramembrane proteases.Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin.Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies The interaction of beta-amyloid protein with cellular membranes stimulates its own production.Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction.The interplay between bioactive sphingolipids and steroid hormones.APP Function and Lipids: A Bidirectional Link.The role of APP proteolytic processing in lipid metabolism.Sphingolipid metabolic pathway: an overview of major roles played in human diseases.Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells.Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons.Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells.

P2860

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P2860

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.

http://www.wikidata.org/entity/Q40415765

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Inhibition of glycosphingolipi ...... tein and amyloid beta-peptide.

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type

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Inhibition of glycosphingolipi ...... tein and amyloid beta-peptide.

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Inhibition of glycosphingolipi ...... tein and amyloid beta-peptide.

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Journal of Biological Chemistry

P1476

Inhibition of glycosphingolipi ...... tein and amyloid beta-peptide.

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P2093

Esther Barth

http://www.w3.org/2001/XMLSchema#string

Irfan Y Tamboli

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Jochen Walter

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Kai Prager

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Konrad Sandhoff

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Michael Heneka

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P2860

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

Functions of lipid rafts in biological membranes

The glycosphingolipidoses-from disease to basic principles of metabolism.

Intracellular transport of GPI-anchored proteins.

A cell biological perspective on Alzheimer's disease.

Intramembrane proteolysis by presenilins.

How proteins move lipids and lipids move proteins.

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

The cell biology of Alzheimer's disease: uncovering the secrets of secretases.

Cholesterol, A beta and Alzheimer's disease.

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28110-28117

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10.1074/JBC.M414525200

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30

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280

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2005-05-27T00:00:00Z

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15923191

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