Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion - Wikidata - awgldk - TriplyDB

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.wikidata.org/entity/Q28294279

about

Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease Mechanisms of Aβ Clearance and Degradation by Glial Cells Exosomes as Novel Regulators of Adult Neurogenic Niches Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.Cross-talk of membrane lipids and Alzheimer-related proteins.Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.Women with the Alzheimer's risk marker ApoE4 lose Aβ-specific CD4⁺ T cells 10-20 years before men.Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo.Wnt3a induces exosome secretion from primary cultured rat microglia.CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia.Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.Molecular mechanisms underlying the effects of statins in the central nervous system.Extracellular membrane vesicles and immune regulation in the brain.Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases.Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space.Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.Exosomes, an Unmasked Culprit in Neurodegenerative Diseases.Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer's Disease.Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles.Microglial microvesicle secretion and intercellular signaling.Proteolytic degradation of amyloid β-protein.Transfer of vesicles from schwann cells to axons: a novel mechanism of communication in the peripheral nervous system Disease modifying drugs targeting β-amyloid.Classical and unconventional pathways of vesicular release in microglia.Extracellular vesicles as mediators of neuron-glia communication.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.Innate immunity in Alzheimer's disease.Extracellular vesicles in Alzheimer's disease: friends or foes? Focus on aβ-vesicle interaction.Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer's disease.Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells.BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

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P2860

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.wikidata.org/entity/Q28294279

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Statins promote the degradatio ...... grading enzyme (IDE) secretion

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

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type

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

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prefLabel

Statins promote the degradatio ...... grading enzyme (IDE) secretion

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

@en

Statins promote the degradatio ...... grading enzyme (IDE) secretion

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JBC.M110.149468

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Journal of Biological Chemistry

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Statins promote the degradatio ...... grading enzyme (IDE) secretion

@en

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Dieter Lütjohann

http://www.w3.org/2001/XMLSchema#string

Esther Barth

http://www.w3.org/2001/XMLSchema#string

Irfan Y Tamboli

http://www.w3.org/2001/XMLSchema#string

Jochen Walter

http://www.w3.org/2001/XMLSchema#string

Karen Tolksdorf

http://www.w3.org/2001/XMLSchema#string

Leonie Christian

http://www.w3.org/2001/XMLSchema#string

Martin Siepmann

http://www.w3.org/2001/XMLSchema#string

Michael T Heneka

http://www.w3.org/2001/XMLSchema#string

Patrick Wunderlich

http://www.w3.org/2001/XMLSchema#string

Sandesh Singh

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

Active caspase-1 is a regulator of unconventional protein secretion

Cholesterol, lipid rafts, and disease

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

ApoE promotes the proteolytic degradation of Abeta

Rab GTPases as coordinators of vesicle traffic

Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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37405-14

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scholarly article

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4637156

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10.1074/JBC.M110.149468

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P433

48

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285

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2010-11-26T00:00:00Z

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20876579

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3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Cytochrome P450, family 51

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2988346

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