Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. - Wikidata - awgldk - TriplyDB

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

http://www.wikidata.org/entity/Q40427821

about

Novel therapeutic targets for pancreatic cancer Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis Full-length L1CAM and not its Δ2Δ27 splice variant promotes metastasis through induction of gelatinase expression Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer.Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.Drug-target residence time: critical information for lead optimization.Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line Matrix metalloproteinases in tumorigenesis: an evolving paradigm.Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition.Selective water-soluble gelatinase inhibitor prodrugs.Conformational analyses of thiirane-based gelatinase inhibitors Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors Matrix Metalloproteinases and Bladder Cancer: What is New?Towards third generation matrix metalloproteinase inhibitors for cancer therapy The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer.Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.Therapeutic modulation of prostate cancer metastasis.Metastasis review: from bench to bedside.Blockade of MMP-2 and MMP-9 inhibits corneal lymphangiogenesis.Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation.Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice.Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment.Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells.CD44 regulates prostate cancer proliferation, invasion and migration via PDK1 and PFKFB4.Down-regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP-2 and inducing mesenchymal-to-epithelial transition.Inhibition of MMP-9 activity following hypoxic ischemia in the developing brain using a highly specific inhibitor.Matrix metalloproteinase-9 potentiates early brain injury after subarachnoid hemorrhage.Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling.Primitive macrophages control HSPC mobilization and definitive haematopoiesis.

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P2860

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

http://www.wikidata.org/entity/Q40427821

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

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type

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Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

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Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

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0008-5472.CAN-04-3570

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Cancer Research

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Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

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P2093

Achim Krüger

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Charlotte Kopitz

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M Margarida Bernardo

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Matthias J E Arlt

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Mayland Chang

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Michael Gerg

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Rafael Fridman

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Shahriar Mobashery

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3523-3526

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scholarly article

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10.1158/0008-5472.CAN-04-3570

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9

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65

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15867341

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