CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis.
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HLA-B27-associated reactive arthritis: pathogenetic and clinical considerationsUse of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitisMHC class I multimersHLA-B27 subtypes differentially associated with disease exhibit subtle structural alterationsDual, HLA-B27 Subtype-dependent Conformation of a Self-peptideCitrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypesLoss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptideThe Cys-67 residue of HLA-B27 influences cell surface stability, peptide specificity, and T-cell antigen presentation.The synovio-entheseal complex in enthesoarthritis.Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes.The immunology of Epstein-Barr virus infectionAnalysis of the CD8+ T cell response to the G1 domain of aggrecan in ankylosing spondylitis.Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype.MHC-bound antigens and proteomics for novel target discovery.A computational docking study on the pH dependence of peptide binding to HLA-B27 sub-types differentially associated with ankylosing spondylitis.When is arthritis reactive?Mechanisms of Disease: the immunopathogenesis of spondyloarthropathies.Investigation of Cardiac Complications and their Incidence in Patients with Ankylosing Spondylitis.The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis.HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells.Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosisThe interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.The C terminus of the nucleoprotein of influenza A virus delivers antigens transduced by Tat to the trans-golgi network and promotes an efficient presentation through HLA class I.Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.Major histocompatibility complex class I-restricted alloreactive CD4+ T cells.HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides.Proinflammatory responses to self HLA epitopes are triggered by molecular mimicry to Epstein-Barr virus proteins in oligoarticular juvenile idiopathic arthritis.Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability.HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum.Preliminary X-ray diffraction analysis of crystals from the recombinantly expressed human major histocompatibility antigen HLA-B*2704 in complex with a viral peptide and with a self-peptide.X-ray diffraction analysis of crystals from the human major histocompatibility antigen HLA-B*2706 in complex with a viral peptide and with a self-peptide.Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 moleculesPurification, crystallization and preliminary X-ray diffraction analysis of the human major histocompatibility antigen HLA-B*2703 complexed with a viral peptide and with a self-peptide.Expression, purification and preliminary X-ray crystallographic analysis of the human major histocompatibility antigen HLA-B*1402 in complex with a viral peptide and with a self-peptideMutation of Cys-67 alters the thermodynamic stability of the human leukocyte antigen HLA0-B*2705.
P2860
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P2860
CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
CD8(+) T-cell autoreactivity t ...... s with ankylosing spondylitis.
@en
type
label
CD8(+) T-cell autoreactivity t ...... s with ankylosing spondylitis.
@en
prefLabel
CD8(+) T-cell autoreactivity t ...... s with ankylosing spondylitis.
@en
P2093
P2860
P356
P1476
CD8(+) T-cell autoreactivity t ...... s with ankylosing spondylitis.
@en
P2093
M L Dupuis
M T Fiorillo
R Sorrentino
P2860
P356
10.1172/JCI9295
P407
P577
2000-07-01T00:00:00Z