Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.
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Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surfaceUpdate on ankylosing spondylitis: current concepts in pathogenesis.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.ERAP1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case-control study and meta-analysis of published series.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligandsChronic inflammatory diseases: do immunological patterns drive the choice of biotechnology drugs? A critical review.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis.Revisiting MHC genes in spondyloarthritis.Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis.Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis.Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han.'MHC-I-opathy'-unified concept for spondyloarthritis and Behçet disease.The role of polymorphic ERAP1 in autoinflammatory diseaseHow ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I ProteinsERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
P2860
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P2860
Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@ast
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@en
type
label
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@ast
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@en
prefLabel
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@ast
Endoplasmic reticulum aminopep ...... entation of multiple antigens.
@en
P2093
P2860
P1433
P1476
Endoplasmic reticulum aminopep ...... sentation of multiple antigens
@en
P2093
Andrea Amalfitano
Charles F Aylsworth
Christopher F Blum
David P W Rastall
Dionisia Quiroga
Irini Evnouchidou
Ram P Kamal
Sarah Godbehere-Roosa
Sergey S Seregin
P2860
P304
P356
10.3109/08916934.2013.819855
P577
2013-09-13T00:00:00Z