Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.
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Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrixMammalian tolloid proteinases: role in growth factor signallingSecreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarctionData comparing the kinetics of procollagen type I processing by bone morphogenetic protein 1 (BMP-1) with and without procollagen C-proteinase enhancer 1 (PCPE-1).Hind limb unloading of mice modulates gene expression at the protein and mRNA level in mesenchymal bone cells.Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity.COL1 C-propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta.Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substratesMetalloproteinases in Drosophila to humans that are central players in developmental processes.Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester UptakeProcollagen C-Proteinase Enhancer 1 (PCPE-1) as a Plasma Marker of Muscle and Liver Fibrosis in MiceProcollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation.The bone morphogenetic protein 1/Tolloid-like metalloproteinasesElucidating the Molecular Composition of Cartilage by Proteomics.Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strengthSecreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention.Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in MiceProteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics.Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only.Binding of procollagen C-proteinase enhancer-1 (PCPE-1) to heparin/heparan sulfate: properties and role in PCPE-1 interaction with cells.Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1).Data comparing the plasma levels of procollagen C-proteinase enhancer 1 (PCPE-1) in healthy individuals and liver fibrosis patients.Enzymatic cleavage specificity of the proalpha1(V) chain processing analysed by site-directed mutagenesis.Matrix and cell phenotype differences in Dupuytren's disease.Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.The proteome and gene expression profile of cementoblastic cells treated by bone morphogenetic protein-7 in vitro.Identification of binding partners interacting with the α1-N-propeptide of type V collagen.Procollagen C-proteinase enhancer 1 (PCPE-1) functions as an anti-angiogenic factor and enhances epithelial recovery in injured cornea.Molecular determinants of Xolloid action in vivo.
P2860
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P2860
Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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name
Substrate-specific modulation ...... vity to be enhanced by PCPE-1.
@en
type
label
Substrate-specific modulation ...... vity to be enhanced by PCPE-1.
@en
prefLabel
Substrate-specific modulation ...... vity to be enhanced by PCPE-1.
@en
P2093
P2860
P50
P356
P1476
Substrate-specific modulation ...... ivity to be enhanced by PCPE-1
@en
P2093
Ake Oldberg
Bernard Font
Catherine Moali
Denise Eichenberger
Florence Ruggiero
Vincent François
P2860
P304
24188-24194
P356
10.1074/JBC.M501486200
P407
P577
2005-04-15T00:00:00Z