about
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applicationsChloroquine is a zinc ionophoreDecreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas.Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actionsTumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer CellsThe Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's DiseaseInvestigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives.A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer.Synthesis and anticancer properties of water-soluble zinc ionophores.Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathicaIdentification of candidate agents active against N. ceranae infection in honey bees: establishment of a medium throughput screening assay based on N. ceranae infected cultured cellsQuinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells.Zinc Protoporphyrin Suppresses β-Catenin Protein Expression in Human Cancer Cells: The Potential Involvement of Lysosome-Mediated DegradationActivation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells.Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.Turning tumor-promoting copper into an anti-cancer weapon via high-throughput chemistryTargeting the progression of Parkinson's disease.Current treatment options for Dientamoeba fragilis infections.Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways.Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation.Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity.Using antimicrobial adjuvant therapy in cancer treatment: a review.Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer.Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status.Toward a molecular understanding of the photosensitizer-copper interaction for tumor destruction.Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol.Zinc at sub-cytotoxic concentrations induces heme oxygenase-1 expression in human cancer cells.Trolox enhances curcumin's cytotoxicity through induction of oxidative stress.Zinc at cytotoxic concentrations affects posttranscriptional events of gene expression in cancer cells.N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell deathCyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.A potential anti-cancer agent: 5-chloro-7-iodo-8-hy-droxy-quinolinium dichlorido(5-chloro-7-iodo-quinolin-8-olato-κN,O)palladium(II) dihydrate.Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM.Evidence for an extracellular zinc-veneer in rodent brains from experiments with Zn-ionophores and ZnT3 knockouts.Evidence that Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore (Clioquinol) Approach.Combination Therapy with Low Copper Diet, Penicillamine and Gamma Knife Radiosurgery Reduces VEGF and IL-8 In Patients with Recurrent GlioblastomaNovel mitochondria targeted copper(ii) complexes of ferrocenyl terpyridine and anticancer active 8-hydroxyquinolines showing remarkable cytotoxicity, DNA and protein binding affinity.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Anticancer activity of the antibiotic clioquinol.
@en
type
label
Anticancer activity of the antibiotic clioquinol.
@en
prefLabel
Anticancer activity of the antibiotic clioquinol.
@en
P2093
P1433
P1476
Anticancer activity of the antibiotic clioquinol.
@en
P2093
Hanako Yamauchi
Joshua L Vaught
Stuart E Lind
Wei-Qun Ding
P304
P356
10.1158/0008-5472.CAN-04-3577
P407
P577
2005-04-01T00:00:00Z