Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
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GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysisLichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell MotilityC-Src-mediated phosphorylation of δ-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin.Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials.Upregulated function of mitochondria-associated ER membranes in Alzheimer diseaseDelta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD14-3-3ɛ/ζ Affects the stability of δ-catenin and regulates δ-catenin-induced dendrogenesis.E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-cateninIdentification of E2F1 as a positive transcriptional regulator for delta-catenin.δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: implications on human prostate cancer progression.Mutant presenilin 1 increases the expression and activity of BACE190K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus.Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells.Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin-p120-Catenin Complex.δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer.Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.Presenilin mutations deregulate mitochondrial Ca homeostasis and metabolic activity causing neurodegeneration inPotassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer
P2860
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P2860
Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Presenilin-1 D257A and D385A m ...... of normal C-terminal fragment.
@en
type
label
Presenilin-1 D257A and D385A m ...... of normal C-terminal fragment.
@en
prefLabel
Presenilin-1 D257A and D385A m ...... of normal C-terminal fragment.
@en
P2093
P2860
P356
P1476
Presenilin-1 D257A and D385A m ...... of normal C-terminal fragment.
@en
P2093
Hangun Kim
Hee-Sae Park
Hyunkyoung Ki
Kwonseop Kim
P2860
P304
22462-22472
P356
10.1074/JBC.M502769200
P407
P577
2005-03-29T00:00:00Z