NLR family pyrin domain containing 3

NLR family pyrin domain containing 3

Item
http://www.wikidata.org/entity/Q4044963
Q21111626
sameAs
NLRP3
P688
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndromePYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa BChronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytesA novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1betaCutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive propertiesNLRs join TLRs as innate sensors of pathogensHearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonismNALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCInflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory responseDe novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseasesPhenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutationsThe adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activationUnified polymerization mechanism for the assembly of ASC-dependent inflammasomes.PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation.
P921

NLR family pyrin domain containing 3

Item
http://www.wikidata.org/entity/Q4044963
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
NLR family pyrin domain containing 3
@en
NLR family pyrin domain containing 3
@nl
NLRP3
@fr
NLRP3
@ru
type
label
NLR family pyrin domain containing 3
@en
NLR family pyrin domain containing 3
@nl
NLRP3
@fr
NLRP3
@ru
altLabel
Angiotensin/vasopressin receptor AII/AVP-like
@en
CLR1.1
@en
NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
@en
NACHT, LRR and PYD containing protein 3
@en
NACHT, LRR and PYD domains-containing protein 3
@en
NALP3
@ru
NLRP3
@en
PYRIN-containing APAF1-like protein 1
@en
caterpiller protein 1.1
@en
cold autoinflammatory syndrome 1 protein
@en
prefLabel
NLR family pyrin domain containing 3
@en
NLR family pyrin domain containing 3
@nl
NLRP3
@fr
NLRP3
@ru
P31
P352
P361
P486
P527
P637
P638
P680
P681
P682
P692
P702
P703
P705
P352
P486
P637
P638
P31
P352
P361
P486
P527
P637
P638
P680
P681
P682
P692
P702
P703
P705