Molecular determinants of the agonist binding domain of a P2X receptor channel.
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesExploring the ATP-binding site of P2X receptorsA histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding siteP2X receptors: dawn of the post-structure era.Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsExperimental characterization and mathematical modeling of P2X7 receptor channel gating.Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.An intersubunit zinc binding site in rat P2X2 receptorsActivation and regulation of purinergic P2X receptor channelsCalcium-dependent block of P2X7 receptor channel function is allosteric.Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.Allosteric modulation of ATP-gated P2X receptor channelsDual gating mechanism and function of P2X7 receptor channels.The P2X7 receptor channel pore dilates under physiological ion conditions.Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity.Structural interpretation of P2X receptor mutagenesis studies on drug actionHeteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Roles of conserved ectodomain cysteines of the rat P2X4 purinoreceptor in agonist binding and channel gating.P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells.Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors.Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopyCharacterisation of ATP analogues to cross-link and label P2X receptorsRole of aromatic and charged ectodomain residues in the P2X(4) receptor functions.Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.Amino acid residues constituting the agonist binding site of the human P2X3 receptorActivation of the P2X7 ion channel by soluble and covalently bound ligands.The Dynamic Behavior of the P2X4 Ion Channel in the Closed Conformation.Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function.Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition.
P2860
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P2860
Molecular determinants of the agonist binding domain of a P2X receptor channel.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Molecular determinants of the agonist binding domain of a P2X receptor channel.
@en
type
label
Molecular determinants of the agonist binding domain of a P2X receptor channel.
@en
prefLabel
Molecular determinants of the agonist binding domain of a P2X receptor channel.
@en
P2093
P356
P1476
Molecular determinants of the agonist binding domain of a P2X receptor channel.
@en
P2093
Melanija Tomic
Stanko S Stojilkovic
Tomas Obsil
Zhaodong Liang
Zonghe Yan
P304
P356
10.1124/MOL.104.010108
P577
2005-01-04T00:00:00Z