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Zinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as MetalloproteinsExploring the ATP-binding site of P2X receptorsA histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding siteSolution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding.Tightening of the ATP-binding sites induces the opening of P2X receptor channelsA P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper.P2X receptors: dawn of the post-structure era.Signal transmission within the P2X2 trimeric receptor.Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.Neuromodulation by extracellular ATP and P2X receptors in the CNS.A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptorRegulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsPore-opening mechanism in trimeric P2X receptor channelsCovalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP.Cloning and characterization of a P2X receptor expressed in the central nervous system of Lymnaea stagnalisFunctional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptorAgonist trapped in ATP-binding sites of the P2X2 receptor.Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal glandActivation and regulation of purinergic P2X receptor channelsExternal Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains.Allosteric modulation of purine and pyrimidine receptors.High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanismCysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channelAllosteric modulation of ATP-gated P2X receptor channelsContribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors.Opposite effects of zinc on human and rat P2X2 receptors.Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targetsInter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.New structure enlivens interest in P2X receptors.Structural interpretation of P2X receptor mutagenesis studies on drug actionP2X receptors as drug targets.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.P2X receptorsRole of aromatic and charged ectodomain residues in the P2X(4) receptor functions.Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
An intersubunit zinc binding site in rat P2X2 receptors
@ast
An intersubunit zinc binding site in rat P2X2 receptors
@en
An intersubunit zinc binding site in rat P2X2 receptors
@nl
type
label
An intersubunit zinc binding site in rat P2X2 receptors
@ast
An intersubunit zinc binding site in rat P2X2 receptors
@en
An intersubunit zinc binding site in rat P2X2 receptors
@nl
prefLabel
An intersubunit zinc binding site in rat P2X2 receptors
@ast
An intersubunit zinc binding site in rat P2X2 receptors
@en
An intersubunit zinc binding site in rat P2X2 receptors
@nl
P2093
P2860
P356
P1476
An intersubunit zinc binding site in rat P2X2 receptors
@en
P2093
Naomi Nagaya
Rachel K Tittle
Shlomo S Dellal
P2860
P304
25982-25993
P356
10.1074/JBC.M504545200
P407
P577
2005-05-16T00:00:00Z