Association of active gamma-secretase complex with lipid rafts.
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Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivityMitochondria-associated membranes as hubs for neurodegenerationCholesterol, statins, and dementia: what the cardiologist should knowPen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Shedding of the p75NTR neurotrophin receptor is modulated by lipid raftsInduction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1.Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.Isoprenoids, small GTPases and Alzheimer's disease.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.Dependency of γ-secretase complex activity on the structural integrity of the bilayer.New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme.Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide productionMolecular mechanisms underlying the effects of statins in the central nervous system.Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.MUC1 is a substrate for gamma-secretaseCholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysinLinking lipids to Alzheimer's disease: cholesterol and beyond.ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant.Proteomics of plasma membrane microdomains.Upregulated function of mitochondria-associated ER membranes in Alzheimer diseaseThe involvement of lipid rafts in Alzheimer's disease.ApoE4 upregulates the activity of mitochondria-associated ER membranes.Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles.Can statins put the brakes on Alzheimer's disease?Links between copper and cholesterol in Alzheimer's disease.Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statinsSubstrate specificity of gamma-secretase and other intramembrane proteases.Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42.Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer diseaseCeramide function in the brain: when a slight tilt is enough.The very many faces of presenilins and the γ-secretase complex.The role of cholesterol metabolism in Alzheimer's disease.The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells.Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.
P2860
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P2860
Association of active gamma-secretase complex with lipid rafts.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Association of active gamma-secretase complex with lipid rafts.
@en
type
label
Association of active gamma-secretase complex with lipid rafts.
@en
prefLabel
Association of active gamma-secretase complex with lipid rafts.
@en
P2093
P1476
Association of active gamma-secretase complex with lipid rafts.
@en
P2093
Ikuo Hayashi
Noriko Isoo
Noriko Noguchi
Patrick C Reid
Takao Hamakubo
Takeshi Iwatsubo
Tatsuhiko Kodama
Yasuomi Urano
Yoshikazu Shibasaki
P304
P356
10.1194/JLR.M400333-JLR200
P577
2005-02-16T00:00:00Z