Pleiotropic role for MYCN in medulloblastoma. - Wikidata - awgldk - TriplyDB

Pleiotropic role for MYCN in medulloblastoma.

Pleiotropic role for MYCN in medulloblastoma.

http://www.wikidata.org/entity/Q40461175

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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics Drugging MYCN through an allosteric transition in Aurora kinase A Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease Medulloblastoma stem cells: Promising targets in medulloblastoma therapy Development and cancer of the cerebellum Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.The prenatal origins of cancer Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model Orthotopic models of pediatric brain tumors in zebrafish Alterations in the nuclear proteome of HIV-1 infected T-cells.Deregulated proliferation and differentiation in brain tumors.Molecular subgroups of medulloblastoma.Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling An animal model of MYC-driven medulloblastoma Clonal selection drives genetic divergence of metastatic medulloblastoma.Myc proteins in brain tumor development and maintenance.MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.Novel cell lines established from pediatric brain tumors.BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.An interferon response gene expression signature is activated in a subset of medulloblastomas Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila.The role of stem cells and progenitors in the genesis of medulloblastoma Role of MYC in Medulloblastoma.Expression and function of the testis-predominant protein LYAR in mice.Medulloblastomics: the end of the beginning.Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer.MYCN is a novel oncogenic target in pediatric T-cell acute lymphoblastic leukemia.A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.Molecular diagnostics of CNS embryonal tumors.Mouse models of medulloblastoma.Review: personalized mice: modelling the molecular heterogeneity of medulloblastoma.

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Pleiotropic role for MYCN in medulloblastoma.

http://www.wikidata.org/entity/Q40461175

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Pleiotropic role for MYCN in medulloblastoma.

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type

label

Pleiotropic role for MYCN in medulloblastoma.

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Pleiotropic role for MYCN in medulloblastoma.

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Genes & Development

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Pleiotropic role for MYCN in medulloblastoma.

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P2093

C David James

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Christopher S Hackett

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David D Goldenberg

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Heather C Flynn Gilmer

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Jasmine Lau

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Joanna J Phillips

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Kim Nguyen

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Kohichi Tanaka

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Mai Nagaoka

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Michael D Taylor

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P2860

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification

Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum

LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation

Altered neural cell fates and medulloblastoma in mouse patched mutants

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1059-1072

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scholarly article

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10.1101/GAD.1907510

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10

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24

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Fredrik J Swartling

William A Weiss

Matthew R Grimmer

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2010-05-01T00:00:00Z

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44608008

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20478998

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medulloblastoma

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2867210

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