Intron retention is a widespread mechanism of tumor-suppressor inactivation.
about
Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisPracticability of detecting somatic point mutation from RNA high throughput sequencing dataHigh-throughput interpretation of gene structure changes in human and nonhuman resequencing data, using ACE.How do messenger RNA splicing alterations drive myelodysplasia?Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.Allelic imbalance of somatic mutations in cancer genomes and transcriptomes.Accurately annotate compound effects of genetic variants using a context-sensitive framework.Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineagesCLASS2: accurate and efficient splice variant annotation from RNA-seq reads.The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulationRNA splicing factors as oncoproteins and tumour suppressors.Lessons from non-canonical splicingIRFinder: assessing the impact of intron retention on mammalian gene expression.Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology.Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems.Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response.Therapeutic targeting of splicing in cancer.Molecular cloning and characterization of two novel genes from hexaploid wheat that encode double PR-1 domains coupled with a receptor-like protein kinase.Splicing factor gene mutations in hematologic malignancies.SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Intron retention as a component of regulated gene expression programs.The role of RNA alternative splicing in regulating cancer metabolism.The bromodomain protein BRD4 regulates splicing during heat shock.Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant.CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification.The role of alternative splicing in cancer.Improving genetic diagnosis in Mendelian disease with transcriptome sequencing.RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits.Intron retention enhances gene regulatory complexity in vertebrates.Natural variation in CIRCADIAN CLOCK ASSOCIATED 1 is associated with flowering time in Brassica rapa.Depletion of somatic mutations in splicing-associated sequences in cancer genomes.Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events.Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.
P2860
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P2860
Intron retention is a widespread mechanism of tumor-suppressor inactivation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Intron retention is a widespread mechanism of tumor-suppressor inactivation.
@en
type
label
Intron retention is a widespread mechanism of tumor-suppressor inactivation.
@en
prefLabel
Intron retention is a widespread mechanism of tumor-suppressor inactivation.
@en
P2093
P50
P356
P1433
P1476
Intron retention is a widespread mechanism of tumor-suppressor inactivation
@en
P2093
Donghyun Park
Eunjung Lee
Jongkeun Lee
Yeon Jeong Kim
P2888
P304
P356
10.1038/NG.3414
P407
P577
2015-10-05T00:00:00Z
P5875
P6179
1015421317