Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.
about
Structure modeling of all identified G protein-coupled receptors in the human genomeStructure and Function of A41, a Vaccinia Virus Chemokine Binding ProteinSmall molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.First pharmacophore model of CCR3 receptor antagonists and its homology model-assisted, stepwise virtual screening.Structural Analysis of Chemokine Receptor-Ligand Interactions.CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.The attraction of chemokines as a target for specific anti-inflammatory therapy.Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 functionCCR1 antagonists in clinical development.Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.Structure-based network analysis of an evolved G protein-coupled receptor homodimer interface.Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptorsPromiscuous drugs as therapeutics for chemokine receptors.Chemokine receptor antagonists: Part 1.Chemokine receptor antagonists: part 2.Chemokines and their receptors: orchestrating a fine balance between health and disease.Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.Targeting chemokine receptors in allergic disease.Pharmacological modulation of chemokine receptor function.What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular MechanismsReversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor.Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5.CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.
P2860
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P2860
Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Site-directed mutagenesis of C ...... chemokine receptor antagonist.
@en
type
label
Site-directed mutagenesis of C ...... chemokine receptor antagonist.
@en
prefLabel
Site-directed mutagenesis of C ...... chemokine receptor antagonist.
@en
P2093
P2860
P356
P1476
Site-directed mutagenesis of C ...... chemokine receptor antagonist
@en
P2093
Filipa Lopes de Mendonça
James E Pease
José W Saldanha
Rhian M Phillips
Timothy J Williams
P2860
P304
P356
10.1074/JBC.M412267200
P407
P577
2004-11-17T00:00:00Z