Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors
about
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disordersLigand binding assays at equilibrium: validation and interpretationStructure and dynamics of the M3 muscarinic acetylcholine receptorAllosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.Allosteric Modulation of Muscarinic Acetylcholine Receptors.Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling biasThe use of G-protein coupled receptor models in lead optimization.FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site.Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptorDevelopment of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsProgress in structure based drug design for G protein-coupled receptors.Are GPCRs still a source of new targets?Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.What is the potential of G protein-coupled receptor [corrected] allosteric sites in drug design?Prediction of consensus binding mode geometries for related chemical series of positive allosteric modulators of adenosine and muscarinic acetylcholine receptors.Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
P2860
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P2860
Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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name
Mutagenic mapping suggests a n ...... arinic acetylcholine receptors
@en
Mutagenic mapping suggests a n ...... rinic acetylcholine receptors.
@nl
type
label
Mutagenic mapping suggests a n ...... arinic acetylcholine receptors
@en
Mutagenic mapping suggests a n ...... rinic acetylcholine receptors.
@nl
prefLabel
Mutagenic mapping suggests a n ...... arinic acetylcholine receptors
@en
Mutagenic mapping suggests a n ...... rinic acetylcholine receptors.
@nl
P2093
P2860
P356
P1476
Mutagenic mapping suggests a n ...... arinic acetylcholine receptors
@en
P2093
Ben G Tehan
Christopher J Langmead
Edward C Hulme
Guillaume Lebon
P2860
P304
P356
10.1124/MOL.108.050963
P577
2008-11-11T00:00:00Z