Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin
about
New developments in aminoglycoside therapy and ototoxicityMechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exonNew approaches to treatment of primary immunodeficiencies: fixing mutations with chemicalsAminoglycoside antibiotics and autism: a speculative hypothesisFunctional Translational Readthrough: A Systems Biology PerspectiveTranslational readthrough potential of natural termination codons in eucaryotes--The impact of RNA sequenceNew approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicalsXBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.Identification of the molecular attributes required for aminoglycoside activity against LeishmaniaNonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak syndrome type 2Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutationsNovel small molecules potentiate premature termination codon readthrough by aminoglycosidesA novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.The major 5' determinant in stop codon read-through involves two adjacent adeninesThe unfolded protein response affects readthrough of premature termination codonsAminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutationsDevelopment of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutationsCorrection of genetic disease by making sense from nonsense.Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cellsTranslational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations.Evidence of efficient stop codon readthrough in four mammalian genesEmerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.Statistical analysis of readthrough levels for nonsense mutations in mammalian cells reveals a major determinant of response to gentamicin.Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals.Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutationsAtaluren treatment of patients with nonsense mutation dystrophinopathy.Mice homozygous for c.451C>T mutation in Cln1 gene recapitulate INCL phenotype.The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice.Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directionsL-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples.Context effects on misreading and suppression at UAG codons in human cells.Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouseNovel compounds for the treatment of Duchenne muscular dystrophy: emerging therapeutic agentsDesigner aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression.G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.
P2860
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P2860
Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Suppression of a nonsense muta ...... ibiotics G-418 and paromomycin
@en
type
label
Suppression of a nonsense muta ...... ibiotics G-418 and paromomycin
@en
prefLabel
Suppression of a nonsense muta ...... ibiotics G-418 and paromomycin
@en
P2860
P356
P1476
Suppression of a nonsense muta ...... ibiotics G-418 and paromomycin
@en
P2093
P2860
P304
P356
10.1093/NAR/13.17.6265
P577
1985-09-01T00:00:00Z