Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.
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Enzymatic methods for glyco(diversification/randomization) of drugs and small moleculesNatural-product sugar biosynthesis and enzymatic glycodiversification.Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coliMetabolically engineered Escherichia coli for efficient production of glycosylated natural products.Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferaseRecombinant E. coli prototype strains for in vivo glycorandomization.Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.The impact of enzyme engineering upon natural product glycodiversificationCombinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexosesKetoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGTInvestigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coliGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes.Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.Structural characterization of enzymatic products in the dTDP-d-Qui4NFo biosynthetic pathway using electrospray ionization tandem mass spectrometry.Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus.Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.Cooperative Involvement of Glycosyltransferases in the Transfer of Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin by Streptomyces sp. Strain CS149
P2860
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P2860
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Engineering biosynthetic pathw ...... the antitumor tetracenomycin.
@en
type
label
Engineering biosynthetic pathw ...... the antitumor tetracenomycin.
@en
prefLabel
Engineering biosynthetic pathw ...... the antitumor tetracenomycin.
@en
P2093
P50
P1476
Engineering biosynthetic pathw ...... the antitumor tetracenomycin.
@en
P2093
José A Salas
Jürgen Rohr
Lisa Greenwell
Miranda Gibson
P304
P356
10.1016/J.CHEMBIOL.2004.10.007
P577
2004-12-01T00:00:00Z