African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages.
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African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA.Unique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X.Involvement of the reparative DNA polymerase Pol X of African swine fever virus in the maintenance of viral genome stability in vivo.The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event.Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation.ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts
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African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages.
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African swine fever virus prot ...... s growth in swine macrophages.
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African swine fever virus prot ...... s growth in swine macrophages.
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African swine fever virus prot ...... s growth in swine macrophages.
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African swine fever virus prot ...... us growth in swine macrophages
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José Salas
María L Salas
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10.1128/JVI.80.10.4847-4857.2006
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2006-05-01T00:00:00Z