Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
about
Molecular targets for flavivirus drug discoveryThe role of viral persistence in flavivirus biologyStructure and functionality in flavivirus NS-proteins: perspectives for drug designStructural proteomics of dengue virusCrystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitorMechanisms of activation and inhibition of Zika virus NS2B-NS3 proteaseAnti-dengue drug: viral polyprotein, a potential targetCleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile virusesExpression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B–NS3 junction regionSwitching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based MutagenesisCrystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionThe C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral ReplicationStructural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefoldCrystal Structure of the NS3 Protease-Helicase from Dengue VirusFunctional Analysis of Potential Carboxy-Terminal Cleavage Sites of Tick-Borne Encephalitis Virus Capsid ProteinYellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic FunctionsThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicaseIdentification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenMechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and BioassaysDiscovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput DockingConservation and Variability of West Nile Virus ProteinsStructure-based discovery of dengue virus protease inhibitorsActivation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanismNMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 ProteaseCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFocus on flaviviruses: current and future drug targetsSerotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus FamilyFlexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implicationsLigand-Bound Structures of the Dengue Virus Protease Reveal the Active ConformationAllosteric Inhibition of the NS2B-NS3 Protease from Dengue VirusDevelopment and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 proteaseStructure of the NS2B-NS3 protease from Zika virus after self-cleavageIntrinsically Disordered Side of the Zika Virus ProteomeCrystal structure of unlinked NS2B-NS3 protease from Zika virusEnzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substratesNMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional DynamicsA brief review on dengue molecular virology, diagnosis, treatment and prevalence in PakistanIdentification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virusBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondA conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.
P2860
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P2860
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Structural basis for the activ ...... om dengue and West Nile virus.
@en
type
label
Structural basis for the activ ...... om dengue and West Nile virus.
@en
prefLabel
Structural basis for the activ ...... om dengue and West Nile virus.
@en
P2093
P2860
P356
P1476
Structural basis for the activ ...... rom dengue and West Nile virus
@en
P2093
Allan D'Arcy
Markus Kroemer
Martin Renatus
Nikolaus Schiering
Paul Erbel
Subhash G Vasudevan
Ulrich Hommel
P2860
P2888
P304
P356
10.1038/NSMB1073
P5008
P577
2006-03-12T00:00:00Z