Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.
about
Molecular targets for flavivirus drug discoveryCrystal Structure of the NS3 Protease-Helicase from Dengue VirusDiscovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput DockingStructure-based discovery of dengue virus protease inhibitorsSerotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus FamilyLigand-Bound Structures of the Dengue Virus Protease Reveal the Active ConformationContemplating 3-Hydroxypropionic Acid Biosynthesis in Klebsiella pneumoniaeBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondVirtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.Designing cyclic peptide inhibitor of dengue virus NS3-NS2B protease by using molecular docking approach.Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Inhibition of dengue virus by targeting viral NS4B proteinUse of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease.Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.Anthracene-based inhibitors of dengue virus NS2B-NS3 proteaseThe flavivirus protease as a target for drug discovery.A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 proteaseIdentification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells.Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffoldProgress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach.Biological activities of guanidine compounds.New developments in flavivirus drug discovery.Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.Dengue Protease Substrate Recognition: Binding of the Prime Side.Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells.Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.RNA-virus proteases counteracting host innate immunity.Conformational flexibility of DENV NS2B/NS3pro: from the inhibitor effect to the serotype influence.The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI.In vitro evaluation of novel inhibitors against the NS2B-NS3 protease of dengue fever virus type 4.Rational discovery of dengue type 2 non-competitive inhibitors.Structure-guided fragment-based in silico drug design of dengue protease inhibitors.Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease.Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease.A practical total synthesis of the microbial alkaline proteinase inhibitor (MAPI).
P2860
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P2860
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@en
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@nl
type
label
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@en
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@nl
prefLabel
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@en
Peptide inhibitors of dengue v ...... rapeptide aldehyde inhibitors.
@nl
P2093
P1476
Peptide inhibitors of dengue v ...... trapeptide aldehyde inhibitors
@en
P2093
Claus Ehrhardt
David Beer
John E Knox
K R Ranga Rao
Ngai Ling Ma
Sejal J Patel
Subhash G Vasudevan
Viral Patel
Wai-Ling Chan
P356
10.1016/J.BMCL.2005.09.049
P407
P577
2005-10-21T00:00:00Z