Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
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N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonistsDopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.Fos expression in response to dopamine D3-preferring phenylpiperazine drugs given with and without cocaineUsing prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in ratsDevelopment of molecular probes for imaging sigma-2 receptors in vitro and in vivo.Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methodsDopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.The σ2 receptor: a novel protein for the imaging and treatment of cancer.Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain.Targeting the dopamine D3 receptor: an overview of drug design strategies.N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum.Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compoundComparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents.Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease.Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats.Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in ratsPET Radiotracers for Imaging the Proliferative Status of Solid Tumors.[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways.Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist.Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain.[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterizationSynthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography studySynthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands.Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores.Pd-Catalyzed Synthesis of Piperazine Scaffolds Under Aerobic and Solvent-Free Conditions.
P2860
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P2860
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Synthesis and in vitro binding ...... dopamine D3 receptor ligands.
@en
type
label
Synthesis and in vitro binding ...... dopamine D3 receptor ligands.
@en
prefLabel
Synthesis and in vitro binding ...... dopamine D3 receptor ligands.
@en
P2093
P1476
Synthesis and in vitro binding ...... l dopamine D3 receptor ligands
@en
P2093
Elizabeth McElveen
Michelle Taylor
Robert H Mach
Robert R Luedtke
Wenhua Chu
P356
10.1016/J.BMC.2004.09.054
P407
P50
P577
2005-01-01T00:00:00Z