Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases.
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Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide AnaloguesThe Conformationally Constrained N -Methanocarba-dT Analogue Adopts an Unexpected C4′- exo Sugar Pucker in the Structure of a DNA HairpinA Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcriptionMechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavirStructure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replicationD-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity.Inhibition of hepatitis B virus polymerase by entecavir.Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.Influence of sugar ring conformation on the transportability of nucleosides by human nucleoside transporters.Polypharmacology of conformationally locked methanocarba nucleosides.
P2860
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P2860
Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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name
Fixed conformation nucleoside ...... HIV-1 reverse transcriptases.
@en
type
label
Fixed conformation nucleoside ...... HIV-1 reverse transcriptases.
@en
prefLabel
Fixed conformation nucleoside ...... HIV-1 reverse transcriptases.
@en
P2093
P1476
Fixed conformation nucleoside ...... HIV-1 reverse transcriptases.
@en
P2093
John G Julias
Paul L Boyer
Victor E Marquez
P304
P356
10.1016/J.JMB.2004.10.021
P407
P577
2005-01-01T00:00:00Z