Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.
about
The Molecular and Structural Basis of HBV-resistance to Nucleos(t)ide AnalogsNucleoside/nucleotide analogues in the treatment of chronic hepatitis BPhosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcriptionMechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavirProbing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kineticsReverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Antiviral treatment of chronic hepatitis B virus (HBV) infectionsHIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.Unveiling the roles of HBV polymerase for new antiviral strategiesPresteady state kinetic investigation of the incorporation of anti-hepatitis B nucleotide analogues catalyzed by noncanonical human DNA polymerasesHepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development.Antiviral therapies: focus on hepatitis B reverse transcriptaseNoncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine.Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.New approaches for quantitating the inhibition of HIV-1 replication by antiviral drugs in vitro and in vivo.Entecavir: a review of its use in the treatment of chronic hepatitis B in patients with decompensated liver disease.A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo.Nucleotide Analogues as Probes for DNA and RNA Polymerases.HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.HIV Reverse Transcriptase Inhibitors
P2860
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P2860
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Delayed chain termination prot ...... y HIV-1 reverse transcriptase.
@en
type
label
Delayed chain termination prot ...... y HIV-1 reverse transcriptase.
@en
prefLabel
Delayed chain termination prot ...... y HIV-1 reverse transcriptase.
@en
P2093
P2860
P356
P1476
Delayed chain termination prot ...... y HIV-1 reverse transcriptase.
@en
P2093
Aleksandr Obikhod
Egor P Tchesnokov
Matthias Götte
P2860
P304
34218-34228
P356
10.1074/JBC.M806797200
P407
P577
2008-10-20T00:00:00Z