Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.
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Human perforin employs different avenues to damage membranesVisualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BStructure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defenseDefining the interaction of perforin with calcium and the phospholipid membraneCalcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasitesStructural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid MembranesCytotoxic proteins and therapeutic targets in severe cutaneous adverse reactionsPerforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytesThe Apicomplexan CDC/MACPF-like pore-forming proteins.The effector T cell response to influenza infectionStructural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients.Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisEGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1Perforin rapidly induces plasma membrane phospholipid flip-flopAberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within EuteleostomiEffects of MACPF/CDC proteins on lipid membranes.Perforin-mediated target-cell death and immune homeostasis.Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic functionPerforin deficiency and susceptibility to cancer.Perforin: more than just a pore-forming protein.Perforin: structure, function, and role in human immunopathology.Perforin activity at membranes leads to invaginations and vesicle formation.Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.Addressing the mysteries of perforin function.Human NK cell lytic granules and regulation of their exocytosisAnalysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.Immunological control of herpes simplex virus infections.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.The battlefield of perforin/granzyme cell death pathways.The structure and function of mammalian membrane-attack complex/perforin-like proteins.Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent mannerCoexpression of human perforin improves yeast-mediated delivery of DNA and mRNA to mammalian antigen-presenting cells.Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs.Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells.Real-time visualization of perforin nanopore assembly.Substituted arylsulphonamides as inhibitors of perforin-mediated lysisRapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.
P2860
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P2860
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Calcium-dependent plasma membr ...... 435, 483, and 485 but not 491.
@en
type
label
Calcium-dependent plasma membr ...... 435, 483, and 485 but not 491.
@en
prefLabel
Calcium-dependent plasma membr ...... 435, 483, and 485 but not 491.
@en
P2093
P2860
P356
P1476
Calcium-dependent plasma membr ...... 435, 483, and 485 but not 491.
@en
P2093
Annette Ciccone
Ilia Voskoboinik
Jamie Fletcher
Kylie Browne
Marie-Claude Thia
P2860
P304
P356
10.1074/JBC.M413303200
P407
P577
2004-12-02T00:00:00Z