Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.
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Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytesLAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicityCell biological steps and checkpoints in accessing NK cell cytotoxicityVaccine applications of flow cytometryTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysPlasmodium cellular effector mechanisms and the hepatic microenvironmentAmiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cellsCD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisPerforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cellsPerforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Dynamic regulation of functionally distinct virus-specific T cells.Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression.Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infectionLiving in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIVExamination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccineIncreased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans.Evaluation of antigen specific recognition and cell mediated cytotoxicity by a modified lysispot assay in a rat colon carcinoma modelTemporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicityCytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.Differential localization of T-bet and Eomes in CD8 T cell memory populations.The immunological synapse: a focal point for endocytosis and exocytosis.Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose.Dynamic analysis of immune and cancer cell interactions at single cell level in microfluidic droplets.Quantitative measurement of F-actin accumulation at the NK cell immunological synapse.High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults.CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer.Combination of immune and viral factors distinguishes low-risk versus high-risk HIV-1 disease progression in HLA-B*5701 subjects.Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry.Intracellular trafficking of perforin: to thwart a killer.Follicular CD8+ T Cells: Origin, Function and Importance during HIV Infection.Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin.
P2860
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P2860
Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Rapid up-regulation and granul ...... D8+ T cell cytotoxic activity.
@en
type
label
Rapid up-regulation and granul ...... D8+ T cell cytotoxic activity.
@en
prefLabel
Rapid up-regulation and granul ...... D8+ T cell cytotoxic activity.
@en
P2093
P2860
P356
P1476
Rapid up-regulation and granul ...... CD8+ T cell cytotoxic activity
@en
P2093
Adam R Hersperger
Gareth A D Hardy
George Makedonas
Keri B Sanborn
Michael R Betts
Pinaki P Banerjee
Rahul Pandey
P2860
P304
P356
10.4049/JIMMUNOL.0803945
P407
P577
2009-05-01T00:00:00Z