Molecular dissection of the events leading to inactivation of the FMR1 gene. - Wikidata - awgldk - TriplyDB

Molecular dissection of the events leading to inactivation of the FMR1 gene.

Molecular dissection of the events leading to inactivation of the FMR1 gene.

http://www.wikidata.org/entity/Q40488250

about

Transcription factor FIGLA is mutated in patients with premature ovarian failure Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders Fragile X syndrome Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells The promise and perils of HDAC inhibitors in neurodegeneration Role of CTCF protein in regulating FMR1 locus transcription From FMRP function to potential therapies for fragile X syndrome.CGG repeat in the FMR1 gene: size matters Ovarian dysfunction and FMR1 alleles in a large Italian family with POF and FRAXA disorders: case report Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing.Improved methodology for assessment of mRNA levels in blood of patients with FMR1 related disorders Methylation of novel markers of fragile X alleles is inversely correlated with FMRP expression and FMR1 activation ratio.Evidence for the toxicity of bidirectional transcripts and mitochondrial dysfunction in blood associated with small CGG expansions in the FMR1 gene in patients with parkinsonism.Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.Clinical and molecular implications of mosaicism in FMR1 full mutations.The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation FMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cells Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications.Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.Comparing ESC and iPSC-Based Models for Human Genetic Disorders Cascade Screening for Fragile X Syndrome/CGG Repeat Expansions in Children Attending Special Education in Sri Lanka.Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.De novo microduplication of the FMR1 gene in a patient with developmental delay, epilepsy and hyperactivity.SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome X-linked mental retardation and epigenetics.Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells.Epigenetics in nucleotide repeat expansion disorders.Bidirectional transcription of trinucleotide repeats: roles for excision repair.Chromatin remodeling in the noncoding repeat expansion diseases.Epigenetics, autism spectrum, and neurodevelopmental disorders.Methotrexate treatment of FraX fibroblasts results in FMR1 transcription but not in detectable FMR1 protein levels.

P2860

Q21710713-F05BE0E3-4881-4AC4-920D-912865B7E8FF Q26739927-A96DE9CD-1594-46B2-BFED-DEAD6E0A405A Q26740071-6E8C74D5-82DE-48E4-8ACD-09E6E86E38C0 Q26995168-BBC36DAB-14D2-4063-A1A7-0334564D6A6D Q27011565-5978F95C-1753-4E23-BB8D-A1C0190AA7F2 Q28077015-5DC91474-0B45-4FB3-A9D3-5CBD6FC5A9A7 Q28080022-FF12E0DB-9B41-466C-9E38-258DD680DC63 Q28087539-6D2CCB82-F188-46DE-99E0-E2ECE1FED42C Q28534708-F6DFC46F-1A9D-4F56-9A44-407020326F59 Q30410502-8FB2AFE5-788A-4A91-8164-83DA998FA7B2 Q30464036-53F360BB-65D4-44D4-B80F-680CB1A520A9 Q33281822-BD1B3279-D2B6-45E0-A225-15AD6AA5ABDD Q33285707-95A1003E-738F-4887-A15F-B06E1C6F56A5 Q33463888-BADB280C-BB75-49F0-9EC3-E2F4106695DF Q33527737-BD2C9D05-1617-47FE-BC01-DFD6D727E1DA Q33617809-03993901-F07E-451F-8883-80AB87195952 Q33775485-34669834-B68B-417E-8C04-D535413899D1 Q34198878-55C43C8A-4D48-4B76-B7AF-04D61929A412 Q34275676-7337CE64-55A1-4B3E-B99C-1E6CE55E0949 Q34469474-7583612F-10D6-49F0-8E75-39729C4F2DC7 Q34530652-67D97450-DD07-4A50-8682-4AC1EECF1149 Q34555504-7A71E1A2-7521-4033-9F37-DFA0827E9BC9 Q35033742-5A8F789A-3AA8-4476-B99B-8A8B0C71089E Q35153436-193E7874-5BFB-48CF-ACFF-177A9AA2FF9C Q35642112-FC67DB7E-11E2-49DA-843A-D22453299805 Q35675960-20FB3777-FCE0-4B83-BBFA-5228C7D0D496 Q35750530-FFD8A585-3164-4D67-B870-E4B003D0B795 Q35875408-9390D6FD-8551-4B6F-9AD3-8714B8AEAAA0 Q35966957-8E30B068-3106-410A-A667-42D884DDDD69 Q36333998-3C695529-5614-4852-94D4-A105DEEBC3AD Q36491908-860BF673-F45F-4AA7-905B-503213164955 Q36498006-965F3EAD-6CD7-4B41-86D9-14C4D413E6AA Q36549606-2ED5A7E2-10A6-4864-BBE2-54FDDCC2644D Q36663018-538056FA-440F-422B-9DE8-04BAF89C16E5 Q36725163-EB137AA3-3442-4CDC-9045-26C4FF5DF0E1 Q36848454-9FE6696B-6FE3-4803-AAFB-45B8C82AF915 Q37038917-78B1FFFE-1DB1-4ED6-96A8-A96E3443B351 Q37134343-F16F95CF-F740-4441-874E-9C969C02362E Q37249145-7D4DA178-3CC4-433C-B00A-7E04C1E7B6AD Q37356074-16DA993A-F4AE-471B-8CEA-2D9F7AF027B3

P2860

Molecular dissection of the events leading to inactivation of the FMR1 gene.

http://www.wikidata.org/entity/Q40488250

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

Molecular dissection of the events leading to inactivation of the FMR1 gene.

@en

type

label

Molecular dissection of the events leading to inactivation of the FMR1 gene.

@en

prefLabel

Molecular dissection of the events leading to inactivation of the FMR1 gene.

@en

P1433

Q40488250-7DBECA58-E562-4A49-9B48-D55140E88823

P1476

Q40488250-C0D77884-346D-49DB-A01C-0203474C2AD9

P2093

Q40488250-28E635FD-48B0-4965-969B-8B56DAE98511

Q40488250-3A662E30-8CE2-408C-8B15-62CC64B827EC

Q40488250-50B4739B-E6A6-472C-A804-08FCE5ED53AF

Q40488250-5F184533-E4CE-4255-B5F7-2FB3DAB0908F

Q40488250-72DEEFC5-942D-44B2-B8FE-78B1E813B69C

Q40488250-74ABA9D2-165B-43FF-AAE3-A0A419A90AFC

Q40488250-8DFCFBF0-F050-4948-AE6E-A7C2AC89F36D

Q40488250-AEF3909E-5E30-46F8-A4A3-B27DEFEB474D

Q40488250-B7834B84-A067-484E-8A93-887923B00574

Q40488250-EFEC9665-2B8F-49AA-84FA-0828E6338752

P2860

Q40488250-0641D2C5-9502-4F14-B265-8F07A6CFAA70

Q40488250-0DBCFF17-544F-48E6-B8DC-62BE66DD68BA

Q40488250-120C5D93-E1DA-4AB2-866A-B4291EF7135D

Q40488250-165F6021-0A43-4AC3-B2D9-B0F6C9104854

Q40488250-1C8FC6F6-9F5D-41BE-A39F-591AAC44EADC

Q40488250-2D2DA7FD-7FBE-4D06-AB6C-8254A2133215

Q40488250-352C1E32-EE3F-4994-97FD-9914942EC54C

Q40488250-4948B498-2FF5-4C10-91C9-8AD39CA9A57B

Q40488250-4E448A7D-082F-4BE1-87F6-EDA8D575F829

Q40488250-51FD8C61-207D-439B-90CD-674FB2B6AF60

P304

Q40488250-43BA6878-AADD-4480-9C8B-329DFC23CD41

P31

Q40488250-42E2518D-E9F7-40BE-B910-D7CD8D238E19

P356

Q40488250-AEBEAE04-90DC-429B-8650-95D8DC5C04D4

P433

Q40488250-EADDFE0E-29AE-4521-8C27-02AED6220B57

P478

Q40488250-C1561B48-6BDF-414C-A7D4-E7D83DE114B1

P577

Q40488250-5B4BAF9C-CB7A-4E66-A690-AB5F178474E1

P5875

Q40488250-B12F29C9-54B1-47C2-A6C2-8A4BA702A4A4

P698

Q40488250-1ECA964A-321C-4145-ABA4-BF6C43ACB2A9

P356

P1433

Human Molecular Genetics

P1476

Molecular dissection of the events leading to inactivation of the FMR1 gene.

@en

P2093

Alessandra Terracciano

http://www.w3.org/2001/XMLSchema#string

Ben Oostra

http://www.w3.org/2001/XMLSchema#string

Claudia Bagni

http://www.w3.org/2001/XMLSchema#string

Elisabetta Tabolacci

http://www.w3.org/2001/XMLSchema#string

Francesca Zalfa

http://www.w3.org/2001/XMLSchema#string

Giovanni Neri

http://www.w3.org/2001/XMLSchema#string

Ilaria Zito

http://www.w3.org/2001/XMLSchema#string

Pietro Chiurazzi

http://www.w3.org/2001/XMLSchema#string

Roberta Pietrobono

http://www.w3.org/2001/XMLSchema#string

Umberto Moscato

http://www.w3.org/2001/XMLSchema#string

P2860

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.

Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations

Recent advances in understanding chromatin remodeling by Swi/Snf complexes

Histone acetyltransferases: function, structure, and catalysis

The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

Cellular memory and the histone code

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

The DNA methyltransferases of mammals

P304

267-277

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDI024

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

14

http://www.w3.org/2001/XMLSchema#string

P577

2004-11-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8162903

http://www.w3.org/2001/XMLSchema#string

P698

15563507

http://www.w3.org/2001/XMLSchema#string