ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.
about
AP4 encodes a c-MYC-inducible repressor of p21Specific activity of class II histone deacetylases in human breast cancer cellsDown-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.Cadmium promotes breast cancer cell proliferation by potentiating the interaction between ERalpha and c-Jun.Preclinical studies of YK-4-272, an inhibitor of class II histone deacetylases by disruption of nucleocytoplasmic shuttling.Regulation of histone deacetylase 4 expression by the SP family of transcription factors.Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter.Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcriptionSilencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo.SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression.Functional role of post-translational modifications of Sp1 in tumorigenesisTamoxifen-stimulated growth of breast cancer due to p21 lossDevelopment of histone deacetylase inhibitors for cancer treatment.Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitorO-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells.Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter.Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferationLithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin.The silent estrogen receptor--can we make it speak?Platelet activating factor-induced expression of p21 is correlated with histone acetylationInsights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer.Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells.Resveratrol Represses Pokemon Expression in Human Glioma Cells.Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer.Estrogen-induced and TAFII30-mediated gene repression by direct recruitment of the estrogen receptor and co-repressors to the core promoter and its reversal by tamoxifen.17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes.
P2860
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P2860
ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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name
ICI182,780 induces p21Waf1 gen ...... MCF-7 breast cancer cell line.
@en
type
label
ICI182,780 induces p21Waf1 gen ...... MCF-7 breast cancer cell line.
@en
prefLabel
ICI182,780 induces p21Waf1 gen ...... MCF-7 breast cancer cell line.
@en
P2093
P2860
P50
P356
P1476
ICI182,780 induces p21Waf1 gen ...... MCF-7 breast cancer cell line.
@en
P2093
Andrew Sunters
David M Vigushin
Faezah Halim
John P Alao
R Charles Coombes
Rana Varshochi
Stephen M Hart
P2860
P304
P356
10.1074/JBC.M408063200
P407
P577
2004-11-19T00:00:00Z