Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
about
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryDNA polymerase family X: function, structure, and cellular rolesDNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancerNSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsNuclear APCInteraction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition.Interacting partners of FEN1 and its role in the development of anticancer therapeutics.Involvement of oxidatively damaged DNA and repair in cancer development and aging.Pol β associated complex and base excision repair factors in mouse fibroblasts.Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapyAPC selectively mediates response to chemotherapeutic agents in breast cancer.Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiencyAdenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and functionMolecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinomaPolycyclic aromatic hydrocarbon (PAH)-DNA adducts and breast cancer: modification by gene promoter methylation in a population-based studyAdenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Interaction between APC and Fen1 during breast carcinogenesis.A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC.Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.Targeting DNA polymerase ß for therapeutic intervention.APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria.Shaping of interphase chromosomes by the microtubule network.1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair.Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells.7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3.
P2860
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P2860
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Tumor suppressor APC blocks DN ...... ty to methylmethane sulfonate.
@en
type
label
Tumor suppressor APC blocks DN ...... ty to methylmethane sulfonate.
@en
prefLabel
Tumor suppressor APC blocks DN ...... ty to methylmethane sulfonate.
@en
P2093
P2860
P356
P1476
Tumor suppressor APC blocks DN ...... ty to methylmethane sulfonate.
@en
P2093
Aruna S Jaiswal
Ramesh Balusu
Satya Narayan
P2860
P304
P356
10.1074/JBC.M409200200
P407
P577
2004-11-16T00:00:00Z