Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency
about
Variant base excision repair proteins: contributors to genomic instabilityBase excision repair and cancerBase excision repairIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancerNovel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesisAlkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.DNA polymerase β-dependent cell survival independent of XRCC1 expressionUNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts.Base excision repair and design of small molecule inhibitors of human DNA polymerase β.Detection and imaging of the free radical DNA in cells--site-specific radical formation induced by Fenton chemistry and its repair in cellular DNA as seen by electron spin resonance, immuno-spin trapping and confocal microscopy.Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damageEffect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis.XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.Interaction between APC and Fen1 during breast carcinogenesis.New paradigms and future challenges in radiation oncology: an update of biological targets and technology.Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation.DNA polymerase beta and PARP activities in base excision repair in living cells.Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells.1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers.Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans.Essential role of DNA base excision repair on survival in an acidic tumor microenvironment.Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients.
P2860
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P2860
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@ast
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@en
type
label
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@ast
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@en
prefLabel
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@ast
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@en
P2860
P1433
P1476
Hypersensitivity phenotypes as ...... ase excision repair deficiency
@en
P2093
Julie K Horton
Samuel H Wilson
P2860
P304
P356
10.1016/J.DNAREP.2006.10.016
P577
2006-11-20T00:00:00Z