Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.
about
Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell linesProliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell linesA proteomic study of cMyc improvement of CHO culture.Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.Host cell protein dynamics in the supernatant of a mAb producing CHO cell line.Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.Towards the molecular characterization of the stable producer phenotype of recombinant antibody-producing NS0 myeloma cells.Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platformDifferential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes.Targeted genetic modification of cell lines for recombinant protein production.Differential response in downstream processing of CHO cells grown under mild hypothermic conditions.Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein productionUsing cell engineering and omic tools for the improvement of cell culture processes.Engineering mammalian cells in bioprocessing - current achievements and future perspectives.Mammalian cells as biopharmaceutical production hosts in the age of omics.Host cell protein analysis in therapeutic protein bioprocessing - methods and applications.Proteins improving recombinant antibody production in mammalian cells.Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants.Microarray profiling of preselected CHO host cell subclones identifies gene expression patterns associated with increased production capacity.Dynamics of unfolded protein response in recombinant CHO cellsFeasibility study of semi-selective protein precipitation with salt-tolerant copolymers for industrial purification of therapeutic antibodies.Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells.Identification of antibody-interacting proteins that contribute to the production of recombinant antibody in mammalian cells.RNA interference of cofilin in Chinese hamster ovary cells improves recombinant protein productivity.Chemostat-based transcriptional analysis of growth rate change and BCL-2 over-expression in NS0 cells.Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming.Molecular portrait of high productivity in recombinant NS0 cells.Toward genomic cell culture engineering.mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.The cold-shock response in mammalian cells: investigating the HeLa cell cold-shock proteome.Engineering of chaperone systems and of the unfolded protein response.Non-invasive UPR monitoring system and its applications in CHO production cultures.Analysis of dynamic changes in the proteome of a Bcl-XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases.Correlation of antibody production rate with glucose and lactate metabolism in Chinese hamster ovary cells.Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
P2860
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P2860
Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Comparative proteomic analysis ...... onal antibody production rate.
@en
type
label
Comparative proteomic analysis ...... onal antibody production rate.
@en
prefLabel
Comparative proteomic analysis ...... onal antibody production rate.
@en
P2093
P50
P356
P1476
Comparative proteomic analysis ...... lonal antibody production rate
@en
P2093
P2860
P304
P356
10.1002/BIT.20272
P577
2004-11-01T00:00:00Z