Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.
about
Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteinsHepatitis C virus glycoprotein folding: disulfide bond formation and association with calnexinBinding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiaeBiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeastProteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol.A proteomic study of cMyc improvement of CHO culture.Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levelsCommon sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes, GRP78 and GRP94Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).The G protein of vesicular stomatitis virus has free access into and egress from the smooth endoplasmic reticulum of UT-1 cells.Quality control in the endoplasmic reticulum: folding and misfolding of vesicular stomatitis virus G protein in cells and in vitro.Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatusThe in vivo association of BiP with newly synthesized proteins is dependent on the rate and stability of folding and not simply on the presence of sequences that can bind to BiP.Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease.Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP.Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.Congenital hypothyroid goiter with deficient thyroglobulin. Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones.Insight into the structure, function, and biosynthesis of factor VIII through recombinant DNA technology.Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.Toward a science of metabolic engineering.Proteins improving recombinant antibody production in mammalian cells.Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformationReduction of BiP levels decreases heterologous protein secretion in Saccharomyces cerevisiae.Calnexin overexpression increases manganese peroxidase production in Aspergillus niger.Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells.Proteomic analysis of enriched microsomal fractions from GS-NS0 murine myeloma cells with varying secreted recombinant monoclonal antibody productivities.Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line.Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.Cellular and metabolic engineering. An overview.Relationship between recombinant activated protein C secretion rates and mRNA levels in baby hamster kidney cells.Cellular processing limits the heterologous expression of secretory component in mammalian cells.Effect of serum-free and serum-containing medium on cellular levels of ER-based proteins in various mouse hybridoma cell lines.Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein.Interleukin-1 beta secretion. A possible multistep process that is regulated in a cell type-specific manner.Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant chinese hamster ovary cells.Adenylosuccinate synthetase: a dominant amplifiable genetic marker in mammalian cells.Interconversion of three differentially modified and assembled forms of BiP.Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells
P2860
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P2860
Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Reduction of endogenous GRP78 ...... rologous protein in CHO cells.
@en
type
label
Reduction of endogenous GRP78 ...... rologous protein in CHO cells.
@en
prefLabel
Reduction of endogenous GRP78 ...... rologous protein in CHO cells.
@en
P2093
P2860
P356
P1476
Reduction of endogenous GRP78 ...... rologous protein in CHO cells.
@en
P2093
P2860
P304
P356
10.1128/MCB.8.10.4063
P407
P577
1988-10-01T00:00:00Z