Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
about
The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylationMetnase mediates resistance to topoisomerase II inhibitors in breast cancer cellsDiscovery of cellular regulation by protein degradationTargeting DNA topoisomerase II in cancer chemotherapyCharacterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIDNA damage associated with mitosis and cytokinesis failurePIASgamma is required for faithful chromosome segregation in human cellsDirect monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activationDNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpointA mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Chromosome tips damaged in anaphase inhibit cytokinesisCoordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance.DNA damage-induced cell death is enhanced by progression through mitosisEffects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochoresTopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresFailure of cell cleavage induces senescence in tetraploid primary cells.Mitotic catenation is monitored and resolved by a PKCε-regulated pathwayRPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage.Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogueAn ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4The analysis of mutant alleles of different strength reveals multiple functions of topoisomerase 2 in regulation of Drosophila chromosome structure.Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads.Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsBUB1 mediation of caspase-independent mitotic death determines cell fate.DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint.The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cellsThe decatenation checkpoint.HU-331: a cannabinoid quinone, with uncommon cytotoxic properties and low toxicity.The why and how of DNA unlinkingSUMO modification of DNA topoisomerase II: trying to get a CENse of it allTopoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.DNA topoisomerase II and its growing repertoire of biological functions.Metnase mediates chromosome decatenation in acute leukemia cells.
P2860
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P2860
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
@en
type
label
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
@en
prefLabel
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
@en
P2093
P1433
P1476
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.
@en
P2093
Dimitrios A Skoufias
Françoise B Lacroix
Leslie Wilson
Paul R Andreassen
Robert L Margolis
P304
P356
10.1016/J.MOLCEL.2004.08.018
P577
2004-09-01T00:00:00Z