DNA topoisomerase II and its growing repertoire of biological functions.
about
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesDNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNAMolecular mechanisms of etoposideStructural Basis of Targeting the Exportin CRM1 in CancerInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyProposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90Drugging topoisomerases: lessons and challengesTopoisomerase II is required for the proper separation of heterochromatic regions during Drosophila melanogaster female meiosisTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoMechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory proteinEffects of DNA supercoiling on chromatin architectureMolecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid LeukemiaTDP2 protects transcription from abortive topoisomerase activity and is required for normal neural functionVoreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase IIAn integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase IICytocidal activities of topoisomerase 1 inhibitors and 5-azacytidine against pheochromocytoma/paraganglioma cells in primary human tumor cultures and mouse cell linesDDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approachExploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionThe relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.DNA topoisomerase II-dependent control of the cell cycle progression in root meristems of Allium cepa.The dynamic interplay between DNA topoisomerases and DNA topology.Controlling gene expression by DNA mechanics: emerging insights and challenges.Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαTOP2β is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugsEnhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models.PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture.Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.Higher expression of topoisomerase II alpha is an independent marker of increased risk of cancer-specific death in patients with clear cell renal cell carcinoma.Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.Biochemical assays for the discovery of TDP1 inhibitorsConvection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.DNA break mapping reveals topoisomerase II activity genome-wide.Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy.Control of the flow properties of DNA by topoisomerase II and its targeting inhibitor.
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DNA topoisomerase II and its growing repertoire of biological functions.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 20 April 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
DNA topoisomerase II and its growing repertoire of biological functions.
@en
DNA topoisomerase II and its growing repertoire of biological functions.
@nl
type
label
DNA topoisomerase II and its growing repertoire of biological functions.
@en
DNA topoisomerase II and its growing repertoire of biological functions.
@nl
prefLabel
DNA topoisomerase II and its growing repertoire of biological functions.
@en
DNA topoisomerase II and its growing repertoire of biological functions.
@nl
P2860
P356
P1476
DNA topoisomerase II and its growing repertoire of biological functions
@en
P2093
John L Nitiss
P2860
P2888
P304
P356
10.1038/NRC2608
P407
P577
2009-04-20T00:00:00Z