An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.
about
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent isletsChronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteEfficient in vivo knock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA.Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptorsDifferential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expressionMechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genesEfficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technologyp38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.Gene expression and silencing for improved islet transplantation.Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.RNA interference for improving the outcome of islet transplantation.Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.Knocking down transport: applications of RNA interference in the study of drug transport proteins.Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic isletsPdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma.ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function.Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.Assessing replication and beta cell function in adenovirally-transduced isolated rodent islets.Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.Anticancer activity of an adenoviral vector expressing short hairpin RNA against BK virus T-ag.
P2860
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P2860
An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
An adenovirus vector for effic ...... ncreatic islets of langerhans.
@en
type
label
An adenovirus vector for effic ...... ncreatic islets of langerhans.
@en
prefLabel
An adenovirus vector for effic ...... ncreatic islets of langerhans.
@en
P2093
P1433
P1476
An adenovirus vector for effic ...... ncreatic islets of langerhans.
@en
P2093
Christopher B Newgard
Koji Takeuchi
Thomas C Becker
P304
P356
10.2337/DIABETES.53.9.2190
P407
P577
2004-09-01T00:00:00Z