Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
about
The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domainsStructural and functional properties of platelet-derived growth factor and stem cell factor receptorsEndoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccinesTyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocketEnigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2ACbl negatively regulates JNK activation and cell deathRoles of E3 ubiquitin ligases in cell adhesion and migration.E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.Effects of partner proteins on BCA2 RING ligase activity.As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemiaBortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiap85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Endocytosis of receptor tyrosine kinasesYRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.Regulation of hematopoietic stem cell fate by the ubiquitin proteasome systemDegradation of activated protein kinases by ubiquitination.USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.Regulation of stem cell function by protein ubiquitylationGain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Gene of the month: KIT.Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.Growth factor therapy sequesters inflammation in affording neuroprotection in cerebrovascular diseases.Regulation of cancer stem cells by RING finger ubiquitin ligases.CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.Ubiquitination and the Regulation of Membrane Proteins.Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.
P2860
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P2860
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
@en
type
label
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
@en
prefLabel
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).
@en
P2093
P1433
P1476
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
@en
P2093
Jack B Longley
Stan Lipkowitz
P304
P356
10.1182/BLOOD-2004-05-1768
P407
P50
P577
2004-08-17T00:00:00Z