The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.
about
Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functionsThe Clinical Relevance of Beta Blockers in Ovarian Carcinoma: A Systematic ReviewMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsβ-Adrenergic inhibition of contractility in L6 skeletal muscle cellsDissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells.Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasisA novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasionPharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.Anchoring junctions as drug targets: role in contraceptive development.Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.Impact of stress on cancer metastasisEffect of chronic restraint stress on human colorectal carcinoma growth in mice.Differences in protein changes between stress-induced premature senescence and replicative senescence states.Epac and PKA: a tale of two intracellular cAMP receptors.EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retractionStress hormone-mediated invasion of ovarian cancer cells.The influence of bio-behavioural factors on tumour biology: pathways and mechanisms.Gene expression profiling of chemically induced rat bladder tumors.Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of EpacRap1 controls cell adhesion and cell motility through the regulation of myosin II.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.Neuroendocrine influences on cancer biology.Small G proteins as key regulators of pancreatic digestive enzyme secretion.Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migrationEPAC proteins transduce diverse cellular actions of cAMP.Structural determinants of Junctional Adhesion Molecule A (JAM-A) function and mechanisms of intracellular signaling.The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Central and peripheral nervous systems: master controllers in cancer metastasis.Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.Epac-Rap signaling reduces oxidative stress in the tubular epithelium.Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expressionRap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.
P2860
Q24646480-D2A8675D-0723-4834-AE54-C0D6480E81C9Q28074666-7A3E2A3B-BD5A-437D-B717-92DA688D0EBCQ28115996-78B49669-E6F9-4F0D-985E-D37CFC17532BQ28742057-06D4D4D9-867F-4EE7-A012-18B2DC076484Q30159521-D9535D84-5B04-4DDF-B771-4CA72179BDB7Q30445485-FAB78D5E-FD63-465E-81AB-6C78D3A5358DQ34211343-2096268E-64DA-4159-940E-B8C70C3EC9F4Q34285076-FB5E8E80-C08F-4641-AB4D-854169D27DE3Q34306163-B0A8B8D8-E50E-4731-995C-D7706C1040DCQ34447181-BAEC28C0-72A7-4029-9608-9AB3C4C37BEAQ34501400-D5D5799A-E46C-45E8-AC83-2488E362BCA7Q34516854-0CABE210-E701-46A2-8BDE-C761FCFB59EDQ34569251-51E16CDF-C447-407B-83AF-8631F664A240Q34667999-04D01C05-09B9-44F8-9B49-AEB2FB32791AQ34742655-8CA0FB34-AC14-420C-B0CB-E5080BB9FD2EQ34792821-196FF510-CBA2-4E8E-8EBE-ADA901F75710Q34813937-0237E102-29E5-4F66-94B5-0F52837490E3Q34979113-D03BB25F-95D2-4F93-B45E-796EAAD3DE0AQ35120288-FFEB9D35-D7A8-41F2-BA5B-F89C38858973Q35135129-1930023A-1FC8-4D16-9CE7-762974D858E4Q35721181-FB857848-6FD2-4165-BB0B-5DF76E6AEB92Q35723724-D68401C7-EECD-43D3-9AD7-646F2E319DC1Q35940362-363313AF-8DB2-4D06-BFF8-20C21235DBC2Q36118074-C4469432-5303-45F7-9EB0-D81C639DD236Q36334968-417ACCAD-95F7-4C18-A856-112D3B8A86CAQ36398745-B14A900A-6848-47A5-BDE1-E2E8906C68A8Q36711265-A33E11EA-55CF-4605-BA65-000FAD547417Q36713229-B977B6BB-9A83-417F-994F-C37807E78559Q37138723-FE294EE7-5CBD-4F13-9507-B127DDCD9F82Q37201168-E3C3101D-8404-43F4-B1B6-37ECE929F50EQ37390882-8BB31E65-51C7-464C-8683-6DAB0F8E9335Q37419733-BF94367D-9ECA-4F48-B77E-FA370FEEFC62Q37604903-727F7F80-6419-417F-AFF5-8B69EFE1C56BQ37632467-F7CD7251-9832-417B-84D4-8385ACA4C29AQ38106901-2CCC9FFF-40BF-4BFD-BC01-EA4EA4138DB8Q40405421-65E39A51-DC13-4F80-B1B3-F5874D08AB7AQ40455755-12C4FB30-06F6-429F-8DAD-525BBD61DEF6Q41358472-C59B9758-FDDD-43F3-889A-34BCD99D5A4FQ41459186-2170EDDC-361B-4B83-B5B9-A70868262F2EQ41839442-2C69806D-D1B3-4FE0-AC9D-BA3CAB080FF2
P2860
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The cAMP-Epac-Rap1 pathway reg ...... not the alpha6beta4 integrin.
@en
type
label
The cAMP-Epac-Rap1 pathway reg ...... not the alpha6beta4 integrin.
@en
prefLabel
The cAMP-Epac-Rap1 pathway reg ...... not the alpha6beta4 integrin.
@en
P2093
P2860
P356
P1476
The cAMP-Epac-Rap1 pathway reg ...... not the alpha6beta4 integrin.
@en
P2093
Arnoud Sonnenberg
Johannes L Bos
Jorrit M Enserink
Leo S Price
Milada Mahic
Trond Methi
P2860
P304
44889-44896
P356
10.1074/JBC.M404599200
P407
P577
2004-08-09T00:00:00Z